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Description

This is the phase 2 trial of retatrutide in individuals with obesity (without type 2 diabetes) in which much of the discussion of this review is focused

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Method Reconstitute the solution in the powder vial with 100ml-500ml of Saline for injection by means of a syringe with an appropriate needle through IV Remove the seal of the vial and wipe closures with disinfectant, then insert the needle of the syringe in the vial through the center of the rubber closure and direct the flow of water toward the glass wall of the vial

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Drug working concentrations and stock preparation were as follows: GLP-1MK-801 and MK-801 (both 50 M, dissolved in aCSF or magnesium-free aCSF), NMDA (100 M, dissolved in magnesium free aCSF), CNQX (10 M, dissolved in DMSO, Alomone Labs), picrotoxin (100 M, dissolved in DMSO)

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