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Decreased levels of TNF- and IL-6 indicate that NNMT inhibition not only modulates metabolism but also improves the inflammatory microenvironment, a key component in metabolic disease development and insulin resistance
This finding is particularly relevant for rotator cuff injuries, where the supraspinatus tendon often cannot bridge large gaps without assistance
Importantly, clinical studies typically have indiscriminately tested interventions and have rarely utilised biomarkers or clinical symptoms to identify treatment responders, so the clinical indications are in some cases based on the authors opinion regarding the rationalisation of different management options
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Actionable Next Steps For those intrigued by the potential of NAD+ and AOD9604: Educate Yourself: Continue to research these compounds through reputable scientific sources
Newson RB, Shaheen SO, Chinn S, Burney PG
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