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Results Dosing of mGIPR-Ab or mGIPR-Ab/GLP-1 produces weight loss To investigate the role of GIPR in energy balance in the CNS, male mice that were fed a high-fat diet (HFD) were administered intracerebroventricular (ICV) injections of varying doses of a fully human anti-human GIPR antibody that cross-reacts with mouse GIPR (mGIPR-Ab)

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doi: 10.1136/bmj.4.5727.69 9 OgunmekanAO

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Preventive Strategies and Dose Optimization Starting at the lowest available dose and titrating slowlyoften called a microdose protocolcan reduce headache incidence significantly