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When extreme cold contacts the skin, blood vessels constrict dramatically in a process called vasoconstriction

A mouse metabolises on a faster clock than a human, and a controlled diet in a cage is not a free-living human diet so even the week-numbers above should be read as the shape of a gradual response, not a promise that a human would see anything on the same calendar

Some individuals respond remarkably while others experience modest benefits

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This can help maintain a steady supply of building blocks for glutathione production