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Diuretics and SGLT2 inhibitors can exacerbate fluid and electrolyte losses, whilst statins are independently associated with muscle-related symptoms

PMID: 22315699

Under physiological conditions, the UA concentration in human blood is approximately 5.8 mg/dL in men and 4.5 mg/dL in women (Suzuki et al., 2013)

While drug chemistry suggests low exposure, uncertainty remains

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