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The safety of this mechanism is part of why GLP-1 based therapies have become so widely studied

Mesolimbic reward system GLP-1 receptor expression Already in 1999 the first neuroanatomical indication for a potential role of GLP-1 in reward emerged

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microdosing begins at lower doses of 1.5 mg for women and 1.8 mg for men.) Month 2: Women: 3 mg once weekly (instead of the standard 5 mg) Men: 3.6 mg once weekly (instead of the standard 5 mg) Month 3: Women: 4.5 mg once weekly (instead of the standard 7.5 mg) Men: 5.4 mg once weekly (instead of the standard 7.5 mg) Afterwards, you can gradually increase tirzepatide doses while remaining below the standard dosing increments

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