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doi:10.1111/j.2040-1124.2010.00022.x
Challenges and Future Directions of GLP-1 'Central Program' Intervention Current challenge: Individual differences and long-term safety Although GLP-1 injections have shown excellent efficacy in clinical trials, their "central plan" interventions still face challenges: Individual metabolic differences There are significant differences in the response of different patients to GLP-1RA, which are related to factors such as gene polymorphism, gut microbiota composition, and metabolic flexibility
Glucagon-driven thermogenesis
In conclusion, this trial demonstrates the superiority of oral semaglutide vs sitagliptin in reducing HbA 1c and body weight from baseline in a predominantly Chinese population with type 2 diabetes, as well as a safety and tolerability profile for semaglutide that is consistent with that of the GLP-1RA class
El receptor de GLP-1 (GLP-1R) pertenece a la familia de receptores de glucagn acoplados a protenaG de claseB2,3
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