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Pyridoxine (B) in high doses is known to interact with certain drugs: it can reduce the therapeutic efficacy of levodopa by increasing peripheral conversion of levodopa to dopamine (vitamin B speeds up decarboxylation)
The depletion of brain GSH has also been observed from both autopsies as well as in vivo MRS studies with aging and varied neurological disorders (Alzheimers disease, Parkinsons disease, etc.)
Arch Biochem Biophys 82: 7077
Possible Side Effects Glutathione is generally well tolerated, but mild side effects can occur
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GH-RH antagonists reduce prostatic enlargement and inflammation in carrageenan-induced chronic prostatitis 95
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