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hippocampal CA3 synapse loss, suppressed neurogenesis and chronic-stress BDNF reduction

This can have effects on the acceptance of therapy or adherence in a patient with type 2 diabetes [20]

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Nausea, vomiting, constipation, low appetite, or reduced food intake can affect sleep, hydration, energy, and concentration

The only differences are in the amount of water added and the resulting concentration, since semaglutide doses are much smaller in milligrams