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As the primary factors for the reduced anticancer effect 1) the reduced delivery and uptake of the anticancer agent, 2) the need for the conversion of molecular oxygen (O 2 ) into reactive oxygen species (ROS), 3) the preferred therapeutic effect against highly proliferating cells, which is reduced under hypoxic conditions, or 4) adaptation of the cancer cells by promoting cell survival and upregulating certain resistance pathways, has been suggested 1,2,3,4,5
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What Results Should Patients Expect
NICE-approved weight management includes dietary modification, orlistat, GLP-1 receptor agonists for specific patients, and bariatric surgery for severe obesity
In this study, glycocalyx was observed in the entire lumen of the channels, making microchannels composed of stiff PDMS a suitable model for mechanistic studies