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The liver metabolizes a significant percentage of most drugs during this first pass
Contact your healthcare provider or pharmacist
But knowing the general trajectory helps set expectations and prevents premature frustration
Distributed throughout the skin, intestine, kidneys, liver, and other organs, DPP-4 not only cleaves incretins, but also other proteins with proline (P) or alanine (A) residues as the second amino acid (Wani et al., 2008)
However, tachyphylaxis (tolerance) develops rapidly within 3-5 days of continuous dosing, food intake returns to baseline levels (Cote et al., 2010)
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