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While not necessarily dangerous, injecting too much semaglutide at once is a good way to give yourself a bad tummy ache

One participant with a placebo developed severe hypoglycemia due to CGM malfunction

Starting with a lower dose (such as 500mg once or twice daily) and gradually increasing may improve tolerability

Summary: Retatrutide fatigue is most pronounced during the dose escalation phase and commonly begins to improve once the dose stabilises, though the precise duration varies between individuals

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Non-oral contraceptive methods such as IUDs, implants, and injections are not affected