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Tesamorelin adds the anabolic counterweight
Weight plateaus are more commonly due to metabolic adaptation and decreased energy expenditure as body weight declines
6.2 Fatty acid metabolism and cardiovascular disease Inhibition of fatty acid oxidation in early HF is part of cardiac metabolic remodeling, but this inhibition progressively leads to mitochondrial dysfunction, which ultimately manifests itself in severe energy metabolism disturbances in advanced HF (139)
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