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2.1.2 Molecular and cellular mechanisms underlying the pathogenesis of AD Amyloid plaques arise from the aggregation of A peptides, particularly A4 2 , which is harmful due to its tendency to form plaques and resist dissolving (Jarrett et al., 1993)

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Dermatologically, both Melanotan I and II can darken moles and cause new lentigines, but multiple case reports and series link Melanotan II use with atypical nevi changes and, in rare cases, melanoma diagnoses temporally associated with use