And while some GLP-1 drugs have been on the market for decades, scientists still arent sure of the long-term effects, Rhea adds
For menopausal women specifically, interactions with hormone replacement therapy should be discussed with a healthcare provider, as both HRT and certain peptides affect metabolic and hormonal pathways
The incretin glucagon-like peptide-1 (GLP-1), released from the gut during food intake, amplifies glucose-stimulated insulin release by binding to and activating its cognate G protein-coupled receptor (GPCR), the GLP-1 receptor (GLP-1R), triggering cAMP generation and downstream Protein Kinase A (PKA) and Exchange Protein Activated by cyclic AMP 2 (Epac2) signalling 5 , a process that has been exploited to develop pharmacological GLP-1R agonists (GLP-1RAs) as T2D therapies
If you or a clinician decide that Wegovy isn't suitable for you, Mounjaro is a popular alternative that works similarly
Beyond weight loss, GLP-1 analogues have other health benefits
During this period, the glucose-lowering and appetite-suppressing effects gradually diminish