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Identifying metabotypes of insulin resistance severity in children with metabolic syndrome
Because of its low IGFBP binding, researchers have noted increased availability of free ligand to target-cell receptors in these model systems compared with native IGF-1
Researchers arent only looking at fibroblast-related signaling or one tissue response
The SURMOUNT-1 study was a placebo-controlled 72-week trial in obese subjects that randomized 2,539 participants without diabetes into four equally large study arms with placebo or one of the three tirzepatide doses (5, 10, or 15 mg once weekly)
doi:10.1371/journal.pone.0198626 (accessible en ligne) 3 - Kadry, Mai
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