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This has important clinical consequences, such as the lack of biological markers [7] and the hindered development of targeted pharmacological treatments
Following the rate determining formation of 8-enolate , this intermediate shows only marginal stabilization over the corresponding transition state and evolves to 8-B4 in a barrierless step
doi: 10.3389/fendo.2023.1273542
J.JarzembowskiJ
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