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Hormonal differences, body composition variation, and differences in fat distribution likely account for the gap

Because they are supplements rather than prescription medications, systemic side effects are less defined, but the lack of clinical testing means overall safety remains uncertain

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And while it's technically possible for a doctor to prescribe Adderall to be used as a weight-loss aid (though the FDA has not approved its safety for that purpose), a dozen experts we talked to said this almost never happens