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doi: 10.3390/ph17081081

Mortalin deficiency suppresses fibrosis and induces apoptosis in keloid spheroids

Human clinical trial evidence (strongest) Cerebrolysin in glaucoma: Multiple small trials (20-60 patients each) showing slowed visual field loss and preserved optic nerve structure over 6-12 months

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A comprehensive panel of primary antibodies was used to detect various proteins: FOXO4, p53, Ser15-phospho-p53, p21 (cyclin-dependent kinase inhibitor 1A), p16 (cyclin-dependent kinase inhibitor 2A), 3-HSD, CYP11A1, CYP17A1 (cytochrome P450 family 17 subfamily A member 1), and several senescence-associated secretory phenotype (SASP) factors including IL-1, IL-1, IL-6, IL-10, TNF-, and TGF-