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In both cases, the concern is over the development of a specific type of thyroid cancer involving the parafollicular cells (aka C cells) of the gland
These findings indicate that HIF-1 was necessary for the observed effects of GLP-1R signalling on glucose metabolism
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For patients already using a GLP-1 receptor agonist but needing stronger blood sugar and weight control, tirzepatide may offer added benefits because of its dual-action mechanism