retatrutide phase 2 nejm 2023 obesity trial results Another Promising Medication (Retatrutide) for Retatrutide: Every Clinical Trial Result

Because vitamin (especially folate) supplementation can efficiently reduce plasma homocysteine levels, further prospective cohort studies and ongoing, randomized, placebo-controlled trials will determine the efficiency of folate supplementation, possibly in combination with vitamins B 12 and B 6 , in the prevention and correction of vascular disorders related to moderate hyperhomocysteinemia

2019;30(4):675-688.e7

A.ClarkeL

This can lead to the depletion of glutathione, which can further compromise the body's ability to detoxify toxins and heavy metals

For example, a doctor may prescribe Ozempic which is approved for type 2 diabetes to instead treat obesity

We dont fully understand this yet, but it is important to keep in mind when considering weight loss distribution in shorter trials and especially when drawing conclusions at early timepoints