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Additionally, MC4R activation is well characterized to suppress appetite [46]

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Severe hypersensitivity reactions (e.g., anaphylaxis and angioedema) have been reported

Subsequently, beneficial effects of FOXO4-DRI have been demonstrated in various age-related models 6,7,8

Because renal TECs are highly metabolically active and heavily rely on mitochondrial oxidative phosphorylation, they are vulnerable to cuproptosis-mediated damage (215)

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