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Diarrhea was observed in 13-16% in tirzepatide patients and 12% in semaglutide patients
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However, other investigations have suggested that several GLP-1RAs may cross the bloodbrain barrier via passive diffusion 251 , a GLP-1R-mediated uptake mechanism 252 or adsorption transcytosis 253 , although different compounds may present with variable degrees of brain penetrance 254
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