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Studies show that NNMT inhibition by 5-amino-1-methylquinolinium significantly reduces nicotinamide metabolism, increases NAM accumulation, improves NAD+ synthesis efficiency by over 30%, and markedly increases mitochondrial ATP production and cellular energy metabolism

Arch Intern Med (2005) 165(10):116772.10.1001/archinte.165.10.1167 22 SavageDGLindenbaumJStablerSPAllenRH