Increased lipid oxidation and energy expenditure : Unlike incretin-based therapies, which primarily affect insulin secretion and glucose metabolism, BRP enhances lipid oxidation, leading to increased fat burning and metabolic activity without causing glycemic instability
In addition, ERK1/2 plays a critical role in regulation of the polyphenol chlorogenic acid-derived Nrf2 transcriptional activation
10.3390/cells10051161 Cells 103 ZeruoY.YiZ.LiuH.YiW
Simultaneous versus staggered dosing could theoretically affect how the peptides interact at tissue sites
Specifically, IKE exerts anti-cancer activity by inducing lipid peroxidation and upregulating ferroptosis genes, including SLC7A11 (73)
Another task to be performed is to identify the functional effector molecules of the driver Latilactobacillus sakei LB-P12 (e.g., SCFAs and bacterial extracellular vesicles) and their pathways for crossing the intestinal epithelial barrier and targeting joint macrophages and chondrocytes