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Unlike proteins, peptides are smaller and more targeted in their effects, making them ideal candidates for therapeutic use
Human data are mostly limited to short-term interventions, and direct measurement of lysosomal activity or autophagic flux in clinical trials remains challenging due to the lack of standardized, non-invasive biomarkers [30]
A study showed that in LPS-induced septic skeletal muscle, melatonin preserves mitochondrial function by maintaining the activity of respiratory chain complexes I and IV, restoring ATP production, and stabilizing mitochondrial membrane potential
Little information is available on stability, but one study found it to be stable in water between pH 4.5-7.4 at 60C for at least two weeks, suggesting both aqueous and some thermal stability
Within the mitochondria, oxidation of 2-methyl (-methyl) branched-chain lipids requires conversion (racemization) of the 2 R stereoisomers to the 2 S configuration
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