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GLP-1 medications work by mimicking a hormone in the body that helps regulate appetite, insulin and glucose
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Most users report minimal discomfort
Once control is gained reduce to twice weekly maintenance, increasing for flares An alternative are the topical calcineurin inhibitors - pimecrolimus cream appears more effective than tacrolimus ointment Intralesional corticosteroids are used very occasionally for resistant cases, although there is a greater risk of atrophy Second-line treatment - antimalarial therapy (used in combination with the above) Hydroxychloroquine (HCQ) - 200400 mg daily
There will certainly be many arguments among experts as to whether this study met a minimum threshold for neuroprotection (preventing brain cells from dying), and my personal opinion would be a cautious MAYBE . The assessment of neuroprotection does not in general have a specific accepted and associated metric (way to measure it), so neuroprotection is largely based on the interpretation of scientists and clinicians
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