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1,4 SUSTAIN 5: add-on basal insulin 1,10 In adult patients with type 2 diabetes on basal insulin metformin Mean change in A1C from baseline at Week 30 Patients with A1C 8% at screening had their background basal insulin dose reduced by 20% at the start of the trial to limit the potential risk of hypoglycemia

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This is sterile water preserved with 0.9% benzyl alcohol, which prevents bacterial growth after the vial is punctured

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However, when combined with insulin or sulfonylureas, the risk increases significantly, and dose adjustments of these medications may be necessary

Inhibit high-voltage-activated calcium currents