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Patients with MetS also have higher levels of vasoconstrictor endothelin-1 in their blood (68).The prevalence of microalbuminuria is higher in patients with Metabolic Syndrome (MetS) (69)
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Inflammation is a central driver of many chronic diseases
has dropped to 37% in 2025, down from nearly 40% in 2022, coinciding with increased GLP-1 use
A landmark historical NEJM analysis of NHLBI-funded cardiovascular studies from 1965 to 1998 found female enrollment (54%) actually exceeded the female share of cardiovascular disease prevalence in the general population (49%), though that pattern reversed once single-sex studies were excluded from the analysis ( [57] )
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