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In addition, recent work suggests that a number of stress paradigms applied to mice early in life leads to reduced concentration of metabolites produced and stored in neurons, namely glutamate, GABA and N -acetylaspartate, almost exclusively in the prefrontal cortex ([77] and references therein)

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This is a risk factor because IGF-1 can enhance the survival and proliferation of malignant cells

Nature 463 , 676680 (2010)

But beyond the celebrity endorsements lies a fascinating scientific story