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This dual action is one reason tirzepatide has generally produced greater average weight loss than semaglutide in several obesity-focused trials

Hayley Miller, medical director of Nurx Weight Management, cautions that supplements tend to be "far more hype than evidence," and "any effect tends to be very modest and highly individual." Kumar shares a similar sentiment, saying that while some GLP-1 supplement ingredients have some research to suggest potential benefits, "the studies we have are generally small and short-term

But there is room for both to exist. Sowa, in fact, sells a supplement called Balanced that features many of the same ingredients as the brands discussed above, including chromium and berberine, though she is clear that she does not consider it to be a substitute for a GLP-1 prescription

J Biol Chem, 2009

Watabe, and T