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[9] People With Suicidal Behavior Some research suggests that weight loss medications may be associated with increased suicidal thoughts in certain individuals

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2007;51(8):1404-1412 Chihara K, Minamitani N, Kaji H, et al

The takeaway from these studies: Obesity is a chronic condition and without ongoing treatment (whether medication, surgery, or intensive behavioral support), biology will try to pull weight back up

Glucagon-receptor activity may add effects on energy use and lipid metabolism