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FIGURE 25 FIGURE 26 FIGURE 27 SAR studies contributed to the design of 35 novel dual inhibitors, among which four compounds, compounds 87 (compound 18) , 88 (compound 19) , 89 (compound 20) , and 90 (compound 21) exhibited comparable binding affinities to PDE1/10A
Animal studies reinforce compartment-specific skeletal changes with CR
Antenatal antioxidant treatment with melatonin to decrease newborn neurodevelopmental deficits and brain injury caused by fetal growth restriction
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We use the model to simulate the metabolic profiles previously observed in Down syndrome and autism and compare the model results to clinical data
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