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Isolated variants X(GD_M2)aX(GD_M2)c showed improved luminescence-based activity on GD_M (Extended Data Fig
Aldose reductase (AR) and glutathione reductase (GR) compete for the cofactor NADPH, which results in a decrease in GSH levels, as well as increased OS
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These experimental results demonstrated that NP4 could activate macrophages, facilitate DCs maturation, increase infiltration of cytotoxic T cells, activate the mouse immune system, and inhibit tumor growth in osteosarcoma
This condition is called chemical leukoderma, chemical-induced vitiligo, or contact leukoderma, depending on the context
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