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Furthermore, a recent resting-state functional magnetic resonance imaging (MRI) analysis of 18 women with obesity or polycystic ovary syndrome (PCOS) randomized to either 16-week semaglutide or placebo showed no significant changes in brain regions associated with depression and suicidality 177
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REDEFINE-1 showed that adding amylin to a GLP-1 backbone improves results
Socioeconomic status, family history of mental and behavioral disorders, and lifestyle-related factors were also considered to account for potential influences on suicide risk