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Mol Biol Rep 2013;40(3):2431-2438

Lymphocyte transformation testing is the most reliable in vitro method to confirm the causative drug, and is particularly useful for confirming anticonvulsant and antituberculosis therapies

Remethylation Methionine synthase uses methylcobalamin and 5-methyl-THF to recycle homocysteine to methionine

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Chronic stress: Physical and emotional stress will increase oxidative stress, leading to lower levels of glutathione

Here, we focused primarily on the acute mitochondrial impact of 5FU, and although we arrived at the combination of 5FU and mitochondrial inhibitors (more specifically, 5FU and metformin) somewhat serendipitously, we have now generated evidence to support the use of 5FU and metformin combinations not only in patients with resistant or relapsed disease as previously suggested by others, but also in treatment-naive, first-line chemotherapy settings