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The released inflammatory mediators lead to the upregulation of adhesion molecules such as ICAM-1 on liver sinusoidal endothelial cells (LSECs) and hepatocytes as well as 2 integrins (CD11b/CD18) on neutrophils, which regulate the aggregation of immune cells through the production of mediators and the expression of adhesion molecules that assist neutrophil adhesion and transit within the sinusoids, adhesion to target cells and dependent oxidative stress, leading to hepatocyte death [19,20,21]

10.1249/MSS.0000000000000914 Med

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More concerning still, the prevalence of severe obesity, defined as a BMI 35 kg/m 2 with at least one comorbidity or a BMI 40, was 9.7% [6]

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