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It has traditionally been limited by certain side effects, however, given that its mechanism of action involves increasing norepinephrine (adrenaline) levels in the body
These are commonly used to treat diabetes and to manage weight/ obesity (especially in those with diabetes) 1 Most GLP-1 agonist side effects occur because these medications change how the digestive system and appetite-regulating pathways work
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Third, research models demonstrate improved tolerability with fewer side effects compared to direct GH administration
In 2021, the FDA issued guidance expecting generic peptide drugs to be produced chemically 3 , signaling that chemical synthesis could be the regulatory default for this drug class