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Nutr Metab (Lond) 8:68 Cava E, Yeat NC, Mittendorfer B (2017) Preserving healthy muscle during weight loss

Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor

This keeps the work aligned with regulatory guidance while still allowing for detailed exploration of how the peptide behaves in various models

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As demand for temperature-sensitive therapies accelerates simultaneously across GLP-1s, oncology, vaccines, and cell therapies, that infrastructure dependence is becoming a growing operational vulnerability