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doi: 10.1128/mbio.00107-23

The central mechanism (MC3R/MC4R) is similar in both sexes

It was developed for hospital use to help people experiencing constipation and diarrhea because they are bedridden or have IBS-C/IBS-D

they are part of the body's communication system for regulating insulin/glucagon secretion, glucose metabolism, appetite, and cardiovascular function

Dai X, Yue Z, Eccleston ME, Swartling J, Slater NKH, Kaminski CF

the copper is coordinated via the imidazole nitrogen of the histidine, the alpha-amino group of the glycine and a deprotonated amide nitrogen, which neutralizes copper redox toxicity and enables non-toxic copper transport