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VAT is the deep fat compartment that surrounds abdominal organs, elevates cardiovascular and metabolic risk markers, and tends to be resistant to diet and exercise interventions that reduce subcutaneous fat

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(2018) 315:E1046E52

Biomarkers including HbA1c, fasting insulin, lipid profiles, and body composition measurements provide the quantitative feedback needed to determine whether the combined approach is producing the intended metabolic effects, whether adjustments to formulation or dosing are needed, and whether the balance between the two therapies remains appropriate as a woman's physiology evolves through and beyond the menopausal transition

Molecular cloning and functional

Proteoglycan synthesis accelerates to provide structural integrity to the extracellular matrix