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Although hypersegmented neutrophils (ie, neutrophils with five or more nuclear lobes) are most often associated with megaloblastic anemia (eg, folic acid or vitamin B12 deficiency, including pernicious anemia), they may also be seen in myelodysplastic syndromes, in patients receiving chemotherapy, or in long-term chronic infections

Several pages imply or state that IND status means some level of FDA endorsement

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