In parallel, clinical translation should incorporate mechanistic biomarkers and patient stratification to balance efficacy and safety, enabling the identification of subgroups most likely to benefit from ferroptosis-targeted interventions
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Therefore, conjugating CP to RGD's active sites may facilitate targeted delivery and enhance interference with tumor cell growth, although further experimental validation is needed to confirm these effects [170]
So why is there a discrepancy between these findings and those of meta-analyses of published Mendelian randomization studies