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Alpsoy S, Aktas C, Uygur R, et al
1 Cohort design, multi-omic data generation, and quality control
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In vascular dementia (VD), chronic cerebral ischemia drives ferroptosis through dual mechanismsiron metabolism imbalance (upregulation of transferrin and its receptor TfR1 and downregulation of iron export protein FPN) results in the buildup of free iron within neurons, while oxidative stress accelerates lipid peroxidation by inhibiting GPX4 synthesis and upregulating ACSL4
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