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First-line approaches recommended by NICE and the NHS include: Dietary modification a balanced, calorie-reduced diet tailored to individual needs, with guidance from a registered dietitian where appropriate Increased physical activity at least 150 minutes of moderate-intensity aerobic activity per week for adults, in line with the UK Chief Medical Officers' physical activity guidelines Behavioural interventions cognitive behavioural therapy (CBT)-based programmes, group support, and self-monitoring strategies For individuals with a BMI of 30 kg/m or above (or 27.5 kg/m in certain ethnic groups), pharmacological treatment may be considered alongside lifestyle interventions, subject to clinical assessment and specific eligibility criteria: Orlistat reduces dietary fat absorption and is available via GP prescription

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Stacene Maroushek of Hennepin Healthcare in Minnesota told CNN

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Because it is modeled after a naturally occurring gastric protein, it is generally well-tolerated by the body