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Human Biology and Health

Its activity in research models is often associated with its interaction with actin monomers , influencing cellular motility and structural dynamics within tissues

Polyubiquitination of signaling molecules such as TRAF2, TRAF6, RIP-1, and NEMO activates the TAK1 and IB kinase (IKK) complexes, leading to NF-B activation and pro-inflammatory cytokine production