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You should not take Contrave if you: Have uncontrolled high blood pressure Have anorexia or bulimia Have or have had seizures Use other medicines that contain bupropion such as Wellbutrin, Wellbutrin SR, Wellbutrin XL, Aplenzin, or Zyban Are undergoing an abrupt discontinuation of alcohol, benzodiazepines, barbiturates, and antiepileptic drugs Drink a lot of alcohol and abruptly stop drinking Have kidney disease Have liver disease (it may cause liver dysfunction or hepatitis) Are depressed or have suicidal feelings Have current or recent (within the past 7-14 days) use of opioids or opiate drugs You should not take Contrave under these circumstances either: If youre pregnant, breastfeeding, or planning to become pregnant If youve taken an MAOI (monoamine oxidase inhibitor), such as Nardil, Parnate, or Marplan in the past 14 days If youre taking any opioids or opiate drugs If youre dependent on opioids or using methadone or buprenorphine If you are in opioid withdrawal If you take opioids or opiates right after stopping Contrave, you may be more sensitive to them and require lower doseswhich poses a risk of overdose

Both fall under the GLP-1 receptor agonist family and are designed to help you lose weight

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Despite these considerations, oral semaglutide remains a viable and effective option, particularly for managing T2D and, depending on whether future clinical trials test for this and yield positive results, potentially for off-label use in weight loss

Periodontitis is associated with decreased Total antioxidant capacity (TAC) [46, 47, 48, 49, 50, 51, 52]

Systematic rotation of injection sites is a critical component of safe and effective tirzepatide administration