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For someone already on antihypertensive drugs, this creates a potential safety issue: blood pressure dropping too low (hypotension) if medications are not adjusted in parallel

Higher doses and shorter durations fit acute healing

In the pivotal STEP 1 trial, participants achieved an average weight loss of approximately 15% of initial body weight over 68 weeks significantly more than the 2.4% seen with placebo

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Born in Switzerland, Thorens completed a doctorate at the University of Geneva and then was a postdoctoral fellow there

This extended clearance period is one reason why withdrawal symptoms with GLP-1 medications tend to develop over weeks rather than days