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Extended continuous exposure to any signaling molecule can lead to receptor downregulation, where cells reduce sensitivity to maintain homeostasis
They found that reduced glutathione synthesis could easily be a key contributor to autism
Further analysis by Western blot showed that rhGPx3 mutant with excess amino acid could be recognized by the monoclonal antibody against the hexahistidine tag, but not in the case of the protein treated with factor Xa (Figure 1a and 1b)
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