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Reducing by one dose level and maintaining there is a valid strategy that preserves most of the weight loss benefit while improving tolerability

2025: Novo Nordisk announced positive Phase 3 ESSENCE trial results for semaglutide in early Alzheimer's disease, reporting statistically significant slowing of cognitive and functional decline a breakthrough data package that could establish GLP-1 therapy as a neuroprotective agent and open an addressable market of 6.5 million Alzheimer's patients in the U.S

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This is a significant development because it is the first oral GLP-1 medication with an FDA-approved indication for weight management

While surgery is invasive, data show it often leads to more durable weight loss compared to medication withdrawal